Men who take relatively high doses of ibuprofen may be at increased risk for fertility problems, early research suggests.
Within just two weeks, it seems that the testosterone-producing hormones in the subjects became linked to the amount of ibuprofen in their blood. "It is also associated with depression and increased risk for cardiovascular events, including heart failure and stroke".
Bernard Jégou, a senior author on the study at the French National Institute of Health and Medical Research, said that he believes that there is no problem in people taking ibuprofen to alleviate pain in the short term but he warns against taking the drug for months on end if it was not absolutely necessary.
One group was given 600mg of ibuprofen twice a day while the other group was given a placebo.
Thankfully, the 31 volunteers recovered after they stopped taking the pills. Samples were taken before and after the trial for comparison.
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The small study, which was published yesterday (Jan. 8) in the journal Proceedings of the National Academy of Sciences, found that men who took 1,200 milligrams of ibuprofen a day for six weeks developed a hormonal condition that is linked with reproductive problems. This is more common in older men than younger ones.
'In the men, luteinizing hormone (LH) and ibuprofen plasma levels were positively correlated, and the testosterone/LH ratio decreased. Essentially testosterone levels were normal but the men in the ibuprofen group had higher amounts of luteinizing hormone, which stimulates testosterone production. Over-the-counter pain-relieving analgesics like Motrin and Advil are some of the most commonly used pharmaceutical compounds in the world used to treat aches, pains, fever, and arthritis.
"However, this is now speculative. However, it is recommended that if men (or women) need to take it for more than 3 days consecutively then they should first consult their family doctor". But they said they were anxious about the effect of ibuprofen on the fertility of long-term users, such as athletes.
Now, before you panic, there's no suggestion yet that occasionally relying on an ibuprofen will make your balls shrivel up and die. In both cases, ibuprofen had a direct effect on the testicles. Epidemiological studies have shown that NSAID exposure was associated with reduced testosterone and congenital malformations; another study showed a drop in a testosterone metabolite among men who were taking ibuprofen regularly.
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