Tuesday, 14 August, 2018

New Research Could Help Breast Cancer Sufferers Avoid Chemotherapy

For some breast cancer patients, the chemo decision may now be easier Breast cancer treatment: More women may avoid chemotherapy thanks to breakthrough research
Steve Townsend | 05 June, 2018, 16:10

According to a research article "Epidemiology of breast cancer in Indian women" by Asia-Pacific Journal of Clinical Oncology, in India, breast cancer has been ranked number one cancer among Indian females.

Hormone-receptor-positive, axillary node-negative disease accounts for approximately half of all cases of breast cancer in the USA, and the National Institutes of Health has previously recommended adjuvant chemotherapy for most patients, the authors write. They are going to change treatment and remove uncertainty for women making decisions, ' Allison Kurian, an oncologist at Stanford University who was not involved in the trial said. The 67 percent of women who were at intermediate risk all had surgery and hormone therapy.

But an immune breakthrough for bowel, breast and ovary cancer has remained elusive.

It is the first time that a patient with late-stage breast cancer has been successfully treated by a form of immunotherapy that uses the patient's own immune cells to find and destroy cancer cells that have formed in the body.

"This new study really gives us good reliable data based on almost 7,000 patients, that if you have an intermediate risk score, you don't benefit from chemotherapy", said Dr. John Rimmer, Breast Cancer Surgeon.

When deciding how to treat a breast cancer patient, doctors have used a 21-gene test. Following this "recalibration" of the genetic test, the researchers estimated that chemotherapy was not justified in 70% of cases of breast cancer.

However, the response rate to even the most successful treatments is relatively low, with one recently trialled therapy showing strong effects in only around 10 per cent of prostate cancer patients.

Previously, only women with scores between 0 to 10 could skip chemotherapy.

Most women with the most common form of early-stage breast cancer can safely skip chemotherapy without hurting their chances of beating the disease, doctors are reporting from a landmark study that used genetic testing to gauge each patient's risk.

Patients under 50 with a score of up to 15 also do not need to undergo the treatment, the research concluded.

Socialist takes over as Spain’s prime minister after corruption scandal
He did so without swearing on the Bible or Crucifix, a first for a Spanish prime minister since the restoration of the democracy. Sanchez toppled Rajoy following a court ruling in a major corruption case involving the conservative leader's Popular Party.


A woman with advanced breast cancer which had spread around her body has been completely cleared of the disease by a groundbreaking therapy that harnessed the power of her immune system to fight the tumours.

Over the years, the Cancer Institute has used its $59.8 million in proceeds for studies trying to improve early detection and to determine which cancers are most unsafe and need heaviest treatment and which are less so.

"Side effects, such as hair loss, severe pain and infertility, can be utterly devastating and linger long after they walk out the hospital doors".

She added: "We hope to see NHS Scotland adopt this practice as soon as possible".

Researchers found that more on 83 percent of the women using hormone therapy alone had not developed a recurrence or additional primary cancer.

"They were able to give the patient's own immune system a major boost". The test, which has been on the market for several years, analyzes the activity of 21 genes to predict a woman's risk of recurrence over 10 years.

Commenting on the results, Professor Bryan Hennessy, clinical lead, Cancer Trials Ireland, said: "This is a globally important breast cancer trial". Oncotype DX and other genomic tests have spurred a trend sure to accelerate following Sunday's report.

"This research is experimental right now", said Dr Rosenberg.

It found that Merck pharmaceutical's drug Keytruda (pembrolizumab) - which famously helped former United States president Jimmy Carter stave off advanced melanoma that had spread to his brain - helped lung cancer patients live 4 to 8 months longer than chemo.

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