Wednesday, 17 October, 2018

American-Japanese duo wins 2018 Nobel Medicine Prize for landmark cancer research

US Japanese Immunologists Win Nobel For Revolutionary Cancer Treatment Nobel Prize in Physiology or Medicine awarded jointly to James P Allison and Tasuku Honjo for discovery of...
Steve Townsend | 04 October, 2018, 14:16

The discovery was applied for the development of cancer drugs that inhibits the activity of the PD-1 so immune cells can continue to attack cancer cells.

The duo will share the Nobel prize sum of about $1.01 million (nine million Swedish kronor or 870,000 euros).

"We now have two drugs or more than two drugs that are based on their seminal work that we use everyday in the clinic to take care of patients with melanoma, lung cancer, kidney cancer".

Two scientists have won the Nobel Prize in medicine for research leading to new successful cancer treatments. "The significance of immunotherapy as a form of cancer treatment will be felt for generations to come", said MD Anderson President Peter WT Pisters.

"'Immune checkpoint therapy' has revolutionized cancer treatment and has fundamentally changed the way we view how cancer can be managed", a tweet from the official Twitter account of the Nobel Prize said. In particular, drugs targeting PD-1 blockade have proved a big commercial hit, offering new options for patients with melanoma, lung and bladder cancers.

Tasuku Honjo and James P. Allison shown in a composite photo.

Their work centers harnessing the immune system in such a way as to arrest the development of cancer.

In a statement to reporters after learning of his award, Allison said he was "honored and humbled".

"In parallel, Tasuku Honjo discovered a protein on immune cells and, after careful exploration of its function, eventually revealed that it also operates as a brake, but with a different mechanism of action".

Melania Trump opens Africa tour with babies
She calls Wednesday's visit to Cape Coast Castle "very emotional" and "really something that people should see and experience". The ceremony took place in Obama Hall at the Emintsimadze Palace, which was renamed in Obama's honor after his visit in 2009.


Allison and Honjo have previously shared the 2014 Tang Prize, touted as Asia's version of the Nobels, for their research. He and James Allison of the University of Texas were jointly awarded the 2018 Nobel Prize in medicine.

Immune checkpoint inhibitor therapy targets proteins made by some immune system cells, as well as some cancer cells.

Allison went into cancer research because he always wanted to be the first person to figure something out. Allison's insight, Perlmann said, was to trigger the brakes instead. Carter announced in 2016 that he no longer needed treatment.

READ | Who is Nobel Medicine Prize victor James P Allison? Allison then spent more than 15 years convincing other scientists and drug companies that his approach could work. Dr. Allison is chairman of the department of immunology at the University of Texas and has spent his career developing strategies for cancer immunotherapy.

Meanwhile, the fact that the literature prize will not be handed over this year has grabbed several headlines.

His research also inspired the name of the Checkpoints, a musical group of cancer researchers for which Allison plays harmonica.

The awards ceremony will be held in Stockholm on December 10.

The Nobel in physics will be announced Tuesday, followed by the award for chemistry on Wednesday and the peace prize on Friday.

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